By Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)
Affecting over 100 million members around the world, retinal ailments are one of the major reasons of irreversible visible impairment and blindness, and applicable research types, specially animal types, are necessary to furthering our realizing of the etiology, pathology, and development of those endemic illnesses. In Animal versions for Retinal Diseases, well-known specialists within the box spotlight invaluable strategies in addition to animal types for the fashionable retinal ailments with the intention to reduction within the assessment, improvement, and development of healing thoughts. starting with an summary of the morphology of the retina, visible habit, and genetics and genomics ways for retinal study, the booklet maintains via overlaying animal versions for the examine of particular human retinal illnesses, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal irritation. As a quantity within the profitable Neuromethods sequence, the chapters offer authoritative experiences of the main widespread ways within the field.
Vital and simple to take advantage of, Animal versions for Retinal Diseases serves to help the $64000 destiny study of ocular investigators, ophthalmologists, and neuroscientists presently delving into this attention-grabbing box of study.
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Additional resources for Animal Models for Retinal Diseases
Gov/homologene) or the Predicted Ortholog section in the Human Ensembl genome browser. Homologene utilizes similarity searches and taxonomy information to group potential orthologs together. Ortholog prediction in Ensembl uses similarity searches combined with a phylogenetic tree strategy to determine the most likely orthologs. The homologene entry for OPA1 (ID:14618) includes the orthologs in mouse, zebrafish, and fruit fly. Due to the increased sensitivity of the ortholog prediction in Ensembl, OPA1 orthologs can be identified for more distant organisms including yeast.
J Neurosci 28:9817–9827 Prusky GT, Alam NM, Douglas RM (2006) Enhancement of vision by monocular deprivation in adult mice. J Neurosci 26: 11554–11561 Schmucker C, Seeliger M, Humphries P, Biel M, Schaeffel F (2005) Grating acuity at different luminances in wild-type mice and in mice lacking rod or cone function. Invest Ophthalmol Vis Sci 46:398–407 Pinto LH, Vitaterna MH, Shimomura K et al (2005) Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse.
Lens and cornea, light blue; annular ligament (AL), purple; blood-filled vessels and sinuses, red; iris argentea, yellow; iris stroma, lentis retractor, and sclera, gray; neural retina (NR), pink; scleral ossicle, dark blue; aqueous humor in outflow tissues, blue–white dots in (a) and (b) and pale blue in (c). Reproduced from (35) Recessive mutations were recovered using the same three-generation mating scheme as described for mouse. Many more lines could be analyzed efficiently and at a cheaper cost than equivalent screens in mice.
Animal Models for Retinal Diseases by Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)